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1

The Effects of a Novel Series of Selective Inhibitors of Arachidonate 5-Lipoxygenase on Anaphylactic and Inflammatory Responses

P. BHATTACHERJEE, N. K. BOUGHTON-SMITH, R. L. FOLLENFANT, L. G. GARLAND, G. A. HIGGS, H. F. HODSON, P. J. ISLIP, W. P. JACKSON, S. MONCADA, A. N. PAYNE, R. W. RANDALL, C. H. REYNOLDS, J. A. SALMON, J.

Journal:

Annals of the New York Academy of Sciences

Year:

1988

Language:

english

File:

PDF, 786 KB

english, 1988

2

ChemInform Abstract: Thienopyridines: Nitric Oxide Synthase Inhibitors with Potent in vivo Activity.

Haydn Beaton, Nigel Boughton-Smith, Peter Hamley, Anant Ghelani, David J. Nicholls, Alan C. Tinker, Alan V. Wallace

Journal:

Year:

2001

File:

PDF, 28 KB

2001

3

Reduction by prostacyclin of acetaminophen-induced liver toxicity in the mouse

Francisco Guarner, Nigel K. Boughton-Smith, Geoffrey J. Blackwell, Salvador Moncada

Journal:

Year:

1988

Language:

english

File:

PDF, 636 KB

english, 1988

4

The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)

David R. Cheshire, Anders Åberg, Gunilla M.K. Andersson, Glen Andrews, Haydn G. Beaton, Timothy N. Birkinshaw, Nigel Boughton-Smith, Stephen Connolly, Tony R. Cook, Anne Cooper, Sally L. Cooper, David

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 355 KB

english, 2011

5

Thienopyridines: nitric oxide synthase inhibitors with potent In vivo activity

Haydn Beaton, Nigel Boughton-Smith, Peter Hamley, Anant Ghelani, David J Nicholls, Alan C Tinker, Alan V Wallace

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 231 KB

english, 2001

6

Design and synthesis of achiral 5-lipoxygenase inhibitors employing the cyclobutyl group

Simon T. Hodgson, Peter J. Wates, Geoffrey J. Blackwell, Caroline Craig, Michael Yeadon, Nigel Boughton-Smith

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 351 KB

english, 1993

7

Role of induced nitric oxide synthase and increased NO levels in zymosan peritonitis in the rat

N. K. Boughton-Smith, A. Ghelani

Journal:

Inflammation Research

Year:

1995

Language:

english

File:

PDF, 164 KB

english, 1995

8

Relationship between arachidonic acid metabolism, myeloperoxidase activity and leukocyte infiltration in a rat model of inflammatory bowel disease

N. K. Boughton-Smith, J. L. Wallace, B. J. R. Whitle

Journal:

Inflammation Research

Year:

1988

Language:

english

File:

PDF, 913 KB

english, 1988

9

Characterisation of nitric oxide synthase activity in the rat colonic mucosa and muscle after endotoxin and in a model of colitis

Nigel K. Boughton-Smith, S. M. Evans, B. J. R. Whittle

Journal:

Inflammation Research

Year:

1994

Language:

english

File:

PDF, 258 KB

english, 1994

10

Actions of nitric oxide on the acute gastrointestinal damage induced by PAF in the rat

Nigel K. Boughton-Smith, Angela M. Deakin, Brendan J. R. Whittle

Journal:

Inflammation Research

Year:

1992

Language:

english

File:

PDF, 537 KB

english, 1992

11

Induction of nitric oxide synthase in rat intestine and its association with tissue injury

N. K. Boughton-Smith, S. M. Evans, B. J. R. Whittle, S. Moncada

Journal:

Inflammation Research

Year:

1993

Language:

english

File:

PDF, 150 KB

english, 1993

12

Actions of nitric oxide on the acute gastrointestinal damage induced by PAF in the rat

Nigel K. Boughton-Smith, Angela M. Deakin, Brendan J. R. Whittle

Journal:

Inflammation Research

Year:

1992

Language:

english

File:

PDF, 537 KB

english, 1992

13

Introduction

J. L. MADARA, N. K. BOUGHTON-SMITH

Journal:

Alimentary Pharmacology & Therapeutics

Year:

1997

Language:

english

File:

PDF, 51 KB

english, 1997

14

Prostaglandin protection of rat colonic mucosa from damage induced by ethanol

J. L. Wallace, B. J. R. Whittle, N. K. Boughton-Smith

Journal:

Digestive Diseases and Sciences

Year:

1985

Language:

english

File:

PDF, 2.26 MB

english, 1985

15

Modulation of human colonic arachidonic acid metabolism by sulfasalazine

C. J. Hawkey, N. K. Boughton-Smith, B. J. R. Whittle

Journal:

Digestive Diseases and Sciences

Year:

1985

Language:

english

File:

PDF, 604 KB

english, 1985

16

The role of leukotrienes in the pathogenesis of gastric ulceration

Nigel K. Boughton-Smith, Brendan J.R. Whittle

Journal:

Pharmacological Research Communications

Year:

1988

Language:

english

File:

PDF, 671 KB

english, 1988

17

Stimulation of gastric alkaline secretion by stable prostacyclin analogues in rat and dog

Brendan J.R. Whittle, Gordon L. Kauffman Jr., Nigel K. Boughton-Smith

Journal:

European Journal of Pharmacology

Year:

1984

Language:

english

File:

PDF, 490 KB

english, 1984

18

Protective effect of S-nitroso-N-acetyl-penicillamine in endotoxin-induced acute intestinal damage in the rat

Nigel K. Boughton-Smith, Iain R. Hutcheson, Angela M. Deakin, Brendan J.R. Whittle, S. Moncada

Journal:

European Journal of Pharmacology

Year:

1990

Language:

english

File:

PDF, 402 KB

english, 1990

19

THE GASTRIC ANTISECRETORY ACTIONS OF PROSTAGLANDIN E2 AND STABLE PROSTACYCLIN ANALOGUES AGAINST DIFFERENT SECRETAGOGUES IN PERFUSED WHOLE-STOMACHS OF RAT OR MOUSE in vitro

N.K. BOUGHTON-SMITH, B.J.R. WHITTLE

Journal:

British Journal of Pharmacology

Year:

1981

Language:

english

File:

PDF, 1006 KB

english, 1981

20

Stimulation and inhibition of prostacyclin formation in the gastric mucosa and ileum in vitro by anti-inflammatory agents

N.K. Boughton-Smith, B.J.R. Whittle

Journal:

British Journal of Pharmacology

Year:

1983

Language:

english

File:

PDF, 1.17 MB

english, 1983

21

Increased metabolism of arachidonic acid in an immune model of colitis in guinea-pigs

N.K. Boughton-Smith, B.J.R. Whittle

Journal:

British Journal of Pharmacology

Year:

1985

Language:

english

File:

PDF, 1.26 MB

english, 1985

22

Increased intestinal formation of Paf in endotoxin-induced damage in the rat

B.J.R. Whittle, N.K. Boughton-Smith, I.R. Hutcheson, J.V. Esplugues, J.L. Wallace

Journal:

British Journal of Pharmacology

Year:

1987

Language:

english

File:

PDF, 314 KB

english, 1987

23

The effect of anti-inflammatory drugs on eicosanoid formation in a chronic model of inflammatory bowel disease in the rat

N.K. Boughton-Smith, J.L. Wallace, G.P. Morris, B.J.R. Whittle

Journal:

British Journal of Pharmacology

Year:

1988

Language:

english

File:

PDF, 1.31 MB

english, 1988

24

Failure of the inhibition of rat gastric mucosal 5-lipoxygenase by novel acetohydroxamic acids to prevent ethanol-induced damage

N.K. Boughton-Smith, B.J.R. Whittle

Journal:

British Journal of Pharmacology

Year:

1988

Language:

english

File:

PDF, 1.05 MB

english, 1988

25

Role of nitric oxide in maintaining vascular integrity in endotoxin-induced acute intestinal damage in the rat

Iain R. Hutcheson, Brendan J.R. Whittle, Nigel K. Boughton-Smith

Journal:

British Journal of Pharmacology

Year:

1990

Language:

english

File:

PDF, 1.30 MB

english, 1990

26

Role of oxygen radicals and arachidonic acid metabolites in the reverse passive Arthus reaction and carrageenin paw oedema in the rat

N.K. Boughton-Smith, A.M. Deakin, R.L. Follenfant, B.J.R. Whittle, L.G. Garland

Journal:

British Journal of Pharmacology

Year:

1993

Language:

english

File:

PDF, 1.43 MB

english, 1993

27

The induction of nitric oxide synthase and intestinal vascular permeability by endotoxin in the rat

Nigel K. Boughton-Smith, Steven M. Evans, Ferenc Laszlo, Brendan J.R. Whittle, Salvador Moncada

Journal:

British Journal of Pharmacology

Year:

1993

Language:

english

File:

PDF, 1.74 MB

english, 1993

28

1,2-Dihydro-4-quinazolinamines: Potent, Highly Selective Inhibitors of Inducible Nitric Oxide Synthase Which Show Antiinflammatory Activity in Vivo

Tinker, Alan C., Beaton, Haydn G., Boughton-Smith, Nigel, Cooper, Sally L., Fraser-Rae, Lynne, Hallam, Kay, Hamley, Peter, McInally, Tom, Nicholls, David J., Pimm, Austen D., Wallace, Alan V.

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 61 KB

english, 2003

29

Actions of prostacyclin (PGI2) and its product, 6-oxo-PGF1α on the rat gastric mucosa in vivo and in vitro

B.J.R. Whittle, N.K. Boughton-Smith, S. Moncada, J.R. Vane

Journal:

Year:

1978

Language:

english

File:

PDF, 546 KB

english, 1978

30

Inhibition by 16, 16-dimethyl PGE2 of ethanol-induced gastric mucosal damage and leukotriene B4 and C4 formation

N.K. Boughton-Smith, B.J.R. Whittle

Journal:

Year:

1988

Language:

english

File:

PDF, 762 KB

english, 1988

31

Interaction between PAF-acether and thromboxane in endotoxin-induced intestinal damage

B.J.R. Whittle, N.K. Boughton-Smith

Journal:

Year:

1988

Language:

english

File:

PDF, 83 KB

english, 1988

32

Relationship between PAF-acether and thromboxane A2 biosynthesis in endotoxin-induced intestinal damage in the rat

N.K. Boughton-Smith, I. Hutcheson, B.J.R. Whittle

Journal:

Year:

1989

Language:

english

File:

PDF, 861 KB

english, 1989

33

Nitric oxide synthase activity in ulcerative colitis and Crohn's disease

N.K. Boughton-Smith, S.M. Evans, B.J.R. Whittle, S. Moncada, C.J. Hawkey, A.T. Cole, M. Balsitis

Journal:

Year:

1993

Language:

english

File:

PDF, 966 KB

english, 1993

34

Biosynthesis and Role of the Endothelium-Derived Vasodilator, Nitric Oxide, in the Gastric Mucosa

B. J. R. WHITTLE, N. K. BOUGHTON-SMITH, S. MONCADA

Journal:

Annals of the New York Academy of Sciences

Year:

1992

Language:

english

File:

PDF, 950 KB

english, 1992

35

Biosynthesis of lipoxygenase and cyclo-oxygenase products from [14C]-arachidonic acid by human colonic mucosa.

Boughton-Smith, N K, Hawkey, C J, Whittle, B J

Journal:

Year:

1983

Language:

english

File:

PDF, 1.07 MB

english, 1983

36

Colorectal leukotriene B4 synthesis in vitro in inflammatory bowel disease: inhibition by the selective 5-lipoxygenase inhibitor BWA4C.

Hawthorne, A B, Boughton-Smith, N K, Whittle, B J, Hawkey, C J

Journal:

Year:

1992

Language:

english

File:

PDF, 1.03 MB

english, 1992

37

Synthesis of nitric oxide from l-arginine by neutrophils. Release and interaction with superoxide anion

McCall, T B, Boughton-Smith, N K, Palmer, R M J, Whittle, B J R, Moncada, S

Journal:

Biochemical Journal

Year:

1989

Language:

english

File:

PDF, 612 KB

english, 1989